Blissel is simply dosed for both initial and maintenance therapy

How to start therapy and maintenance1

Blissel can be started any time after the manifestation of symptoms.

Initial treatment: One applicator-dose of vaginal gel per day for 3 weeks (suitably at bedtime).

Maintenance treatment: One applicator-dose of vaginal gel twice a week (suitably at bedtime) is recommended. An evaluation of treatment continuation after 12 weeks should be carried out by the physician.

For initiation and continuation of treatment of post-menopausal symptoms, the lowest effective dose for the shortest duration should be used.

For oestrogen products for vaginal application of which the systemic exposure to the oestrogen remains within the normal postmenopausal range, it is not recommended to add a progestagen.

Missed doses1

A missed dose should be administered as soon as remembered, unless it is more than 12 hours overdue. In the latter case the missed dose should be skipped, and the next dose should be administered at the normal time.

See the summary of product characteristics for full prescribing information.1

How your patient can use BlisselⓇ1

Blissel is applied into the vagina using the dose-marked applicator. “Instructions for use” are included in the information leaflet.

One applicator-dose (applicator filled to the mark) gives a dose of 1 g vaginal gel containing 50 micrograms of estriol. The filled applicator should be inserted into the vagina and emptied. Blissel should be given preferably in the evening.

How to explain Blissel use to your patient

To apply the gel, the patient should lie down, with knees bent and spread apart.

The open end of the applicator should be gently inserted deep into the vagina and the plunger slowly pushed all the way down, as far as it will go, to empty the gel into the vagina.

Release her confidence from within.

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How Blissel


Ultra low dose estriol vaginal gel2

Prescribing and Adverse event reporting information for Blissel can be found here.

 Adverse events should be reported. Reporting forms and information can be found at or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Consilient Health (UK) Ltd, No. 1 Church Road, Richmond upon Thames, Surrey TW9 2QE UK or 

  1. Blissel 50 micrograms/g vaginal gel. Summary of product characteristics. 2. Cano A, et al. Menopause. 2012;19(10):1130-9.

Date of preparation: Jan 2024 | UK-BLS-43e(1)