How to use guide
BlisselⓇ is easy to use, and you should not feel uncomfortable when giving yourself the medication. One dose of BlisselⓇ is 1g (one applicator full) given as your prescription directs.
BlisselⓇ is inserted gently into the vagina using an applicator to ensure the medication is given where it is needed. You can usually do this in the evening before you go to bed.
Once you have given yourself the medication, the applicator can be washed clean for reuse.
More details can be found in the patient information leaflet, which is included in your medication packet.
Your doctor or nurse can also talk you through how to use BlisselⓇ.


BlisselⓇ is easy to use, and you should not feel uncomfortable when giving yourself the medication. One dose of BlisselⓇ is 1g (one applicator full) given as your prescription directs.
BlisselⓇ is inserted gently into the vagina using an applicator to ensure the medication is given where it is needed. You can usually do this in the evening before you go to bed.
Once you have given yourself the medication, the applicator can be washed clean for reuse.
More details can be found in the patient information leaflet, which is included in your medication packet. You can click here to download a PDF guide.
Your doctor or nurse can also talk you through how to use BlisselⓇ.
Further Information

Who to talk to
There are lots of people you can talk to about BlisselⓇ if you need help or support, including the healthcare professional who prescribed you the medication or your pharmacist.
If you have any concerns about your treatment or your medication, or if you experience any side effects, please discuss them with your doctor, nurse or pharmacist.

Patient information leaflet
Your medication will come with a patient information leaflet included in the packet. Keep hold of it so that you can look at it later if you need to.
The leaflet will tell you all about your treatment, including how to use BlisselⓇ, how often you can take it, and other information about the effects of the medication.
Support Groups
There are a number of different groups that can provide you with help and support with the menopause and vaginal atrophy. These organisations can be really beneficial by providing a safe and caring place to talk about your symptoms, treatment and the effects that these have on you.
The Menopause Charity was founded to provide information, advice and support both to women with menopausal symptoms and healthcare professionals who want to provide the best evidence-based care for their patients.

Reporting of side effects: If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet.
You can also report side effects directly via the Yellow Card Scheme at yellowcard.mhra.gov.uk.
Date of preparation: July 2025
UK-BLS-43k(1)